Anti-APP-C31 | Caspase 3 cleaved APP, C terminal fragment
SKU: BTL-AGR-A-02340 | Host: Rabbit | Brand: Agrisera
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| Cat Number | AS21 4570 |
|---|---|
| Category | Primary Antibody |
| Pack Size | 100 µl |
| Description | The Alzheimer Amyloid Precursor Protein (APP) is a transmembrane protein whose abnormal processing is associated with the pathogenesis of Alzheimer’s disease. APP695 lacking the protease inhibitor domain is the predominant form in neuronal tissues. APP695 is cleaved by caspases into the 664-residue amino (N)-terminal fragment that lacks the carboxyl C-terminal 31-residues (APPC31) and the 31-residues C-terminal fragment (APP-C31). Both fragments might be potent inducers of neuronal apoptosis. An antibody (named ACT1) against the N-terminus of caspase 3-generated APP C-terminal 31 aa of human APP695 (APP-C31 ) was raised in rabbit. |
| Applications | ELISA (ELISA), Immunolocalisation (IL), Western blot (WB) |
| Immunogen | Synthetic peptide corresponding to the N-terminal of human caspase 3-generated APP C-terminal 31 amino acids (aa 665-670) UniProt: P05067 |
| Host | Rabbit |
| Form | Liquid |
| Molecular Weight | 86.9 | 100 kDa |
| Dilution Range | 1::500 - 1: 1000 (IL), 1:1000-1:3000 (WB) |
| Uniprot Number | P42574 |
| Purity | Serum. Contains 0.05% sodium azide. |
| Specie Reactivity | Human, Mouse, Rat |
| Expected Reactivity | Species of your interest not listed? Contact us |
| Reconstitution | For reconstitution, add µl of sterile water |
| Storage | Store at -20°C; make aliquots to avoid repeated freeze-thaw cycles. Please remember to spin the tubes briefly prior to opening them to avoid any losses that might occur from material adhering to the cap or sides of the tube. |
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| Note | The product is for research use only |